Realization of micro flow path with hardly adhesive COP resin
Attention device material in medical/life science fieldFukae-Kasei Co.,Ltd


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Realize micro flow path made of COP resin having a groove width of several μm ~ several tens μm with bonding technology

Learnning Points

  • Combining new technology with plastic microfabrication technology
  • Surface modified bonding technology to overcome difficult adhesion
  • Pursuing possibility of surface modification

Micro flow paths that can be active in medical and life science fields

Fukae Kasei Co., Ltd., which manufactures and develops micro processed plastic injection molded products and manufactures expendable lifecycle supplies succeeded in developing COP (Cycloolefin polymers) resinous micro flow path which is also used for medical applications such as test equipment and blood analysis cells.
Due to the plastic microfabrication technology that we have cultivated over more than 10 years, especially the groove processing technology and surface modification bonding technology, the path to commercialization has primarily opened up.

The expectation of COP resin micro flow path

To join resins together, it is necessary to use an adhesive or to fuse them by heat. However, in the field of biotechnology and life science, it is difficult to use adhesives because eluting substances derived from resins are cytotoxic or there is a possibility of affecting reactions. Also, in the case of thermal welding, the microfabricated shape collapsed, so it could not be used for the microchannel in the same field.

Our surface modification bonding technology has made it possible to modify the bonding surface of the COP resin at the molecular level and join it without affecting the microfabricated shape. COP resin has numerous desirable properties such as high flow, precision molding, high transfer, high transparency, low adsorption, peeling, chemical resistance.
Our grooved processing which is ultra-fine processing technology by plastic injection molding can be molded up to the width of a few μm and furthermore by combining surface modification technology it is possible to create relatively complex micro flow paths relatively freely.
It is said that future microfluidic channels made of COP resin are expected to be incorporated into blood test kits that can be performed with less blood and reagents.

Study the joining of dissimilar materials

When cell culture essential for regenerative medicine etc. is performed, it is known that the hydrophilicity of the surface of the substrate such as a petri dish, the functional group on the surface and the electric charge influence the proliferation and differentiation of the cell. In particular, it is said that culture of adherent cells is capable of adsorbing cells on the surface of the substrate, and it is assumed that the charge of the cell surface layer and compatibility of the substrate are the key to culture. Since its compatibility varies depending on cell type, surface modification methods and coatings have been attempted in various fields.
In the field of biotechnology and life science, adhesion methods that do not use adhesives are very suitable for products in this field, as materials eluting from the resin may be cytotoxic or may affect reactions.
In addition to developing a culture plate, we who realized bonding of hard-to-adhere COP resin, further investigated the joining of other adhesives and dissimilar materials including PMMA (acrylic resin), PC (polycarbonate), etc., are progressing accumulation of original research and know-how involved.

  • The micro flow path is an instrument that accumulates extremely fine flow paths, and it is possible to shorten the experiment time and the analysis time with a small number of cells/reagents, and it is expected to improve the efficiency of experiments of chemistry and biology.
    Our micro flow path using COP resin will attract attention in the field of biochip plates and microreactors expected as critical components of medical inspection systems.

company information

Research on microorganisms, cells, DNA, proteins, blood, etc. with two pillars of plastic microfabrication technology capable of mass production of several tens of micrometers in size and product development know-how specialized in fundamental research in the state-of-the-art life science and medical fields, We are developing indispensable laboratory equipment. We respond to custom made custom products and joint development from planning and design to mass production.

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